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Article

Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells

30 Mar 2011

Abstract excerpt

BACKGROUND: Conflicting research has identified METCAM/MUC18, an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family, as both a tumor promoter and a tumor suppressor in the development of breast cancer. To resolve this, we have re-investigated the role of this CAM in the progression of human breast cancer cells. METHODS: Three breast cancer cell lines were used for the tests: one...

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PMID: 21450088
DOI: 10.1186/1471-2407-11-113

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