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Article

Structure, function and evolution of the animal mitochondrial replicative DNA helicase.

Critical reviews in biochemistry and molecular biology - 1 Jan 2016

Kaguni Laurie S, Oliveira Marcos T

Abstract excerpt

The mitochondrial replicative DNA helicase is essential for animal mitochondrial DNA (mtDNA) maintenance. Deleterious mutations in the gene that encodes it cause mitochondrial dysfunction manifested in developmental delays, defects and arrest, limited life span, and a number of human pathogenic phenotypes that are recapitulated in animals across taxa. In fact, the replicative mtDNA helicase was discovered with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26615986
DOI: 10.3109/10409238.2015.1117056
PMCID: PMC4733421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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