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Article

Functional importance of the conserved N-terminal domain of the mitochondrial replicative DNA helicase.

Biochimica et biophysica acta - 1 May 2009

Matsushima Yuichi, Kaguni Laurie S

Abstract excerpt

The mitochondrial replicative DNA helicase is an essential cellular protein that shows high similarity with the bifunctional primase-helicase of bacteriophage T7, the gene 4 protein (T7 gp4). The N-terminal primase domain of T7 gp4 comprises seven conserved sequence motifs, I, II, III, IV, V, VI, and an RNA polymerase basic domain. The putative primase domain of metazoan mitochondrial DNA helicases has diverged...

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Identifiers

PMID: 19063859
DOI: 10.1016/j.bbabio.2008.11.005
PMCID: PMC2711004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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