Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted mutations in Val101 and Arg27 interferon beta protein increase its transcriptional and translational activities.

Cytokine - 1 Feb 2016

Kay Maryam, Hasan-Abad Amin Moradi, Hojati Zohreh, Korbekandi Hasan

Abstract excerpt

Interferon β (IFNβ) is the most prescribed drug that has been used frequently for the treatment of multiple sclerosis (MS) patients. The aim of this study is to improve the production of IFNβ by induction of site directed mutagenesis. Accordingly, recombinant constructs were designed in order to enhance the expression of IFNβ mRNA and protein. The recombinant plasmids were transfected to the CHO cell line,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Codon
Share to Cricetulus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interferon-beta

Share to Mutagenesis, Site-Directed

Share to Protein Biosynthesis

Share to Real-Time Polymerase Chain Reaction

Share to Transfection

Source

Identifiers

PMID: 26615566
DOI: 10.1016/j.cyto.2015.11.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted mutations in Val101 and Arg27 interferon beta protein increase its transcriptional and translational activities.PMID 26615566Read ↗

In Silico and In Vitro Investigations On Mutated IFNβ-scFv Against Human Collagen Type IISemantic proximity Read ↗

Carboxy-terminal truncated rhuIFN-gamma with a substitution of Gln133 or Ser132 to leucine leads to higher biological activity than in the wild type.Semantic proximity Read ↗

Analysis of Association Between Genetic Heterogeneity of Interferon Beta Receptor Promoter and Therapeutic Response to Interferon-beta in a Patient with Multiple SclerosisSemantic proximity Read ↗

Association study of promoter polymorphisms of interferon alpha and beta receptor subunit 1 (IFNAR1) gene and therapeutic response to interferon-beta in patients with multiple sclerosis.Semantic proximity Read ↗

Evaluating the ability of different chaperones in improving soluble expression of a triple-mutated human interferon gamma in Escherichia coli.Semantic proximity Read ↗

Myxovirus resistance protein A (MxA) polymorphism is associated with IFNβ response in Iranian multiple sclerosis patients.Semantic proximity Read ↗

IFNA2 p.Ala120Thr impairs the inhibitory activity of Interferon-α2 against the hepatitis B virus through altering its binding to the receptor.Semantic proximity Read ↗

Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta).Semantic proximity Read ↗

Targeted mutations in IFNα2 improve its antiviral activity against various viruses.Semantic proximity Read ↗

Methods for preparation of recombinant cytokine proteins V. mutant analogues of human interferon-gamma with higher stability and activity.Semantic proximity Read ↗

Targeted mutations in IFNα2 improve its antiviral activity against various virusesSemantic proximity Read ↗

Interferon-beta changes the expression of IL10, IL23A and FOXP3 on Multiple Sclerosis patients' T cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.