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Article

Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta).

Pharmaceutical research - 1 Apr 1998

Runkel L, Meier W, Pepinsky R B, Karpusas M, Whitty A, Kimball K, Brickelmaier M, Muldowney C, Jones W, Goelz S E

Abstract excerpt

PURPOSE: Two recombinant IFN-beta products have been approved for the treatment of multiple sclerosis, a glycosylated form with the predicted natural amino acid sequence (IFN-beta-1a) and a non-glycosylated form that has a Met-1 deletion and a Cys-17 to Ser mutation (IFN-beta-1b). The structural basis for activity differences between IFN-beta-1a and IFN-beta-1b, is determined. METHODS: In vitro antiviral,...

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Identifiers

PMID: 9587963
DOI: 10.1023/a:1011974512425

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