Article
Four-locus gene interaction between IL13, IL4, FCER1B, and ADRB2 for asthma in Chinese Han children.
Pediatric pulmonology - 1 Apr 2016
Hua Li, Zuo Xian-Bo, Bao Yi-Xiao, Liu Quan-Hua, Li Jing-Yang, Lv Jie, Fang Ding-Zhu, Lin Qian, Bao Jun, Ji Ruo-Xu
Abstract excerpt
RATIONALE: IL13, IL4, IL4RA, FCER1B, and ADRB2 are important inflammatory genes associated with immunoglobulin E levels. This study attempts to determine whether there are gene-gene interactions in the five genes among asthmatic children of Chinese Han nationality. METHODS: Nine single-nucleotide polymorphisms (SNPs) in the five genes were genotyped in 1,000 asthmatic children and 1,000 healthy controls using...
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