Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mycobacterium tuberculosis PPE68 and Rv2626c genes contribute to the host cell necrosis and bacterial escape from macrophages.

Virulence - 1 Jan 2016

Danelishvili Lia, Everman Jamie, Bermudez Luiz E

Abstract excerpt

Alveolar macrophages are the main line of innate immune response against M. tuberculosis (Mtb) infection. However, these cells serve as the major intracellular niche for Mtb enhancing its survival, replication and, later on, cell-to-cell spread. Mtb-associated cytotoxicity of macrophages has been well documented, but limited information exists about mechanisms by which the pathogen induces cell necrosis. To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Bacterial
Share to Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages, Alveolar

Share to Mycobacterium tuberculosis

Share to Necrosis

Share to Transcriptome

Share to Tuberculosis

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 26605666
DOI: 10.1080/21505594.2015.1102832
PMCID: PMC4871676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mycobacterium tuberculosis PPE68 and Rv2626c genes contribute to the host cell necrosis and bacterial escape from macrophages.PMID 26605666Read ↗

An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.Semantic proximity Read ↗

Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis.Semantic proximity Read ↗

Mycobacterium tuberculosis Induces an Atypical Cell Death Mode to Escape from Infected MacrophagesSemantic proximity Read ↗

<i>Mycobacterium tuberculosis</i> PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?Semantic proximity Read ↗

Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophagesSemantic proximity Read ↗

Host‐pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infectionSemantic proximity Read ↗

Mycobacterium tuberculosis replicates within necrotic human macrophagesSemantic proximity Read ↗

Different modalities of host cell death and their impact on <i>Mycobacterium tuberculosis</i> infectionSemantic proximity Read ↗

C-terminal region of Rv1039c (PPE15) protein of Mycobacterium tuberculosis targets host mitochondria to induce macrophage apoptosisSemantic proximity Read ↗

Cell death paradigms in the pathogenesis of Mycobacterium tuberculosis infectionSemantic proximity Read ↗

Innate immunity in tuberculosis: how the sensing of mycobacteria and tissue damage modulates macrophage deathSemantic proximity Read ↗

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.