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Mycobacterium tuberculosis replicates within necrotic human macrophages

27 Feb 2017

Abstract excerpt

Mycobacterium tuberculosis modulation of macrophage cell death is a well-documented phenomenon, but its role during bacterial replication is less characterized. In this study, we investigate the impact of plasma membrane (PM) integrity on bacterial replication in different functional populations of human primary macrophages. We discovered that IFN-γ enhanced bacterial replication in macrophage colony-stimulating...

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PMID: 28242744
DOI: 10.1083/jcb.201603040

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