Article
The workings of the amyloid diseases.
Annals of medicine - 1 Jan 2007
Bellotti Vittorio, Nuvolone Mario, Giorgetti Sofia, Obici Laura, Palladini Giovanni, Russo Paola, Lavatelli Francesca, Perfetti Vittorio, Merlini Giampaolo
Abstract excerpt
The amyloidoses constitute a large group of diseases caused by an alteration in the conformation and metabolism of several globular proteins which, under particular conditions, deposit in tissues as insoluble fibrillar aggregates. To date, at least 24 different proteins have been recognized as causative agents of amyloid diseases. Despite a high heterogeneity in amino acid sequence, three-dimensional structure,...
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