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Article

XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer

25 Nov 2015

Abstract excerpt

PURPOSE: Combination of radiation with radiosensitizing chemotherapeutic agents improves outcomes for locally advanced rectal cancer. Current treatment includes 5-fluorouracil-based chemoradiation prior to surgical resection; however pathologic complete response varies from 15% to 20%, prompting the need to identify new radiosensitizers. Exportin 1 (XPO1, also known as chromosome region 1, CRM1) mediates the...

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PMID: 26603256
DOI: 10.1158/1078-0432.ccr-15-0978

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