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Structural basis of Lewis b antigen binding by the Helicobacter pylori adhesin BabA

7 Aug 2015

Abstract excerpt

Helicobacter pylori is a leading cause of peptic ulceration and gastric cancer worldwide. To achieve colonization of the stomach, this Gram-negative bacterium adheres to Lewis(b) (Le(b)) antigens in the gastric mucosa using its outer membrane protein BabA. Structural information for BabA has been elusive, and thus, its molecular mechanism for recognizing Le(b) antigens remains unknown. We present the crystal...

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PMID: 26601230
DOI: 10.1126/sciadv.1500315

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