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Article

Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.

Gastroenterology - 1 Mar 2010

Ahmed-Belkacem Abdelhakim, Ahnou Nazim, Barbotte Laetitia, Wychowski Czeslaw, Pallier Coralie, Brillet Rozenn, Pohl Ralf-Torsten, Pawlotsky Jean-Michel

Abstract excerpt

BACKGROUND & AIMS: Silymarin is a mixture of flavonolignans extracted from the milk thistle. Silymarin contains several molecules, including silibinin A, silibinin B, isosilibinin A, isosilibinin B, silicristin, and silidianin. Intravenous infusion of silibinin induces dose-dependent reduction of hepatitis C virus (HCV) RNA levels. The aim of this study was to test the principal isomers contained in silymarin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19962982
DOI: 10.1053/j.gastro.2009.11.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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