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Article

HCN and KV7 (M-) channels as targets for epilepsy treatment.

Neuropharmacology - 1 Jun 2013

Shah Mala M, Huang Zhuo, Martinello Katiuscia

Abstract excerpt

Voltage-gated ion channels are important determinants of cellular excitability. The Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) and KV7 (M-) channels are voltage-gated ion channels. Both channels are activated at sub-threshold potentials and have biophysical properties that mirror each other. KV7 channels inhibit neuronal excitability. Thus, mutations in KV7 channels that are associated with Benign...

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Identifiers

PMID: 22446478
DOI: 10.1016/j.neuropharm.2012.03.005
PMCID: PMC4104618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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