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Article

Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase.

Scientific reports - 23 Nov 2015

Lidor O, Al-Quntar A, Pesci E C, Steinberg D

Abstract excerpt

Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen responsible for many human infections. LasI is an acyl-homoserine lactone synthase that produces a quorum-sensing (QS) signal that positively regulates numerous P. aeruginosa virulence determinants. The inhibition of the LasI protein is therefore an attractive drug target. In this study, a novel in silico to in vitro complementation was applied to...

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PMID: 26593271
DOI: 10.1038/srep16569
PMCID: PMC4655403

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