Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).

doi:10.1093/jb/mvv114

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).

Journal of biochemistry - 1 Jan 2016

Kitamura Toshio, Watanabe-Okochi Naoko, Enomoto Yutaka, Nakahara Fumio, Oki Toshihiko, Komeno Yukiko, Kato Naoko, Doki Noriko, Uchida Tomoyuki, Kagiyama Yuki, Togami Katsuhiro, Kawabata Kimihito C, Nishimura Koutarou, Hayashi Yasutaka, Nagase Reina, Saika Makoto, Fukushima Tsuyoshi, Asada Shuhei, Fujino Takeshi, Izawa Yuto, Horikawa Sayuri, Fukuyama Tomofusa, Tanaka Yosuke, Ono Ryoichi, Goyama Susumu, Nosaka Tetsuya, Kitaura Jiro, Inoue Daichi

Abstract excerpt

Recent progress in high-speed sequencing technology has revealed that tumors harbor novel mutations in a variety of genes including those for molecules involved in epigenetics and splicing, some of which were not categorized to previously thought malignancy-related genes. However, despite thorough identification of mutations in solid tumors and hematological malignancies, how these mutations induce cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Hematologic Neoplasms

Share to Hematopoietic Stem Cells

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Oncogene Proteins, Fusion

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 26590301
DOI: 10.1093/jb/mvv114
PMCID: PMC4882650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel working hypothesis for pathogenesis of hematological malignancies: combination of mutations-induced cellular phenotypes determines the disease (cMIP-DD).PMID 26590301Read ↗

The molecular basis of myeloid malignancies.Semantic proximity Read ↗

An overview: from discovery of candidate mutations to disease modeling and transformation mechanisms of acute leukemia.Semantic proximity Read ↗

Etiology of Acute Leukemia. A ReviewSemantic proximity Read ↗

BRCA2 promoter hypermethylation as a biomarker for the leukemic transformation of myeloproliferative neoplasms.Semantic proximity Read ↗

[Cytogenetic abnormalities and gene mutations in myeloid leukemia].Semantic proximity Read ↗

[I.Genetic Abnormalities Associated with Acute Leukemia and a Development of Molecular Therapies].Semantic proximity Read ↗

Research progress on gene mutations and drug resistance in leukemia.Semantic proximity Read ↗

[Genetic diagnosis for leukemias by oncogenes].Semantic proximity Read ↗

STAT5a and SH2B3 novel mutations display malignancy roles in a triple-negative primary myelofibrosis patient.Semantic proximity Read ↗

Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemiaSemantic proximity Read ↗

The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model.Semantic proximity Read ↗

Group comparison based on genetic information reveals lineage-specific therapeutic vulnerabilities in acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.