Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pharmacogenetics of taxanes: impact of gene polymorphisms of drug transporters on pharmacokinetics and toxicity.

Pharmacogenomics - 1 Dec 2012

Jabir Rafid Salim, Naidu Rakesh, Annuar Muhammad Azrif Bin Ahmad, Ho Gwo Fuang, Munisamy Murali, Stanslas Johnson

Abstract excerpt

Interindividual variability in drug response and the emergence of adverse drug effects are the main causes of treatment failure in cancer therapy. Functional membrane drug transporters play important roles in altering pharmacokinetic profile, resistance to treatment, toxicity and patient survival. Pharmacogenetic studies of these transporters are expected to provide new approaches for optimizing therapy. Taxanes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Docetaxel
Share to Multidrug Resistance-Associated Protein 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organic Anion Transporters, Sodium-Independent

Share to Paclitaxel

Share to Pharmacogenetics

Share to Precision Medicine

Share to Solute Carrier Organic Anion Transporter Family Member 1B3

Share to Taxoids

Source

Identifiers

PMID: 23215890
DOI: 10.2217/pgs.12.165

Genes

ABCB1
ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pharmacogenetics of taxanes: impact of gene polymorphisms of drug transporters on pharmacokinetics and toxicity.PMID 23215890Read ↗

Genetic polymorphisms and paclitaxel- or docetaxel-induced toxicities: A systematic review.Semantic proximity Read ↗

Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability - considerations for drug development.Semantic proximity Read ↗

Part 2: pharmacogenetic variability in drug transport and phase I anticancer drug metabolism.Semantic proximity Read ↗

Role of Genetic Polymorphisms in Drug-Metabolizing Enzyme-Mediated Toxicity and Pharmacokinetic Resistance to Anti-Cancer Agents: A Review on the Pharmacogenomics Aspect.Semantic proximity Read ↗

The role of OATP1B1 and OATP1B3 transporter polymorphisms in drug disposition and response to anticancer drugs: a review of the recent literatureSemantic proximity Read ↗

Interethnic differences of cytochrome P450 gene polymorphisms may influence outcome of taxane therapy in Roma and Hungarian populations.Semantic proximity Read ↗

Pharmacogenomics of ABC transporters and its role in cancer chemotherapy.Semantic proximity Read ↗

Single nucleotide polymorphisms to predict taxanes toxicities and effectiveness in cancer patients.Semantic proximity Read ↗

Pharmacogenetics of irinotecan metabolism and transport: an update.Semantic proximity Read ↗

Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapySemantic proximity Read ↗

Ethnic differences in the metabolism, toxicology and efficacy of three anticancer drugs.Semantic proximity Read ↗

Transporters and drug-drug interactions: important determinants of drug disposition and effects.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.