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Article

Complement in hemolytic anemia

19 Nov 2015

Abstract excerpt

Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55. Patients with atypical hemolytic uremic syndrome (aHUS) develop a thrombotic microangiopathy (TMA) that in most cases is attributable to mutations...

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PMID: 26582375
DOI: 10.1182/blood-2015-06-640995

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