Article
Complement in hemolytic anemia.
Hematology. American Society of Hematology. Education Program - 1 Jan 2015
Brodsky Robert A
Abstract excerpt
Complement is increasingly being recognized as an important driver of human disease, including many hemolytic anemias. Paroxysmal nocturnal hemoglobinuria (PNH) cells are susceptible to hemolysis because of a loss of the complement regulatory proteins CD59 and CD55. Patients with atypical hemolytic uremic syndrome (aHUS) develop a thrombotic microangiopathy (TMA) that in most cases is attributable to mutations...
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