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Article

Biochemical and Behavioral Evaluation of Human MAPT Mutations in Transgenic Drosophila melanogaster.

Biochemical genetics - 1 Feb 2016

Haddadi Mohammad, Nongthomba Upendra, Ramesh S R

Abstract excerpt

Mutations in the human microtubule-associated protein tau (hMAPT) gene including R406W and V337M result in autosomal dominant neurodegenerative disorder. These mutations lead to hyperphosphorylation and aggregation of Tau protein which is a known genetic factor underlying development of Alzheimer's disease (AD). In the present study, transgenic Drosophila models of AD expressing wild-type and mutant forms of...

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PMID: 26581847
DOI: 10.1007/s10528-015-9701-1

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Biochemical and Behavioral Evaluation of Human MAPT Mutations in Transgenic Drosophila melanogaster.PMID 26581847Read ↗

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