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Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer.

Breast (Edinburgh, Scotland) - 1 Feb 2016

Tokunaga Eriko, Yamashita Nami, Kitao Hiroyuki, Tanaka Kimihiro, Taketani Kenji, Inoue Yuka, Saeki Hiroshi, Oki Eiji, Oda Yoshinao, Maehara Yoshihiko

Abstract excerpt

PURPOSE: INPP4B is considered to function as a putative tumor suppressor through its inhibitory function of Akt. In various malignant tumors, loss of heterozygosity (LOH) at the chromosomal region containing INPP4B and lower expression of INPP4B has been reported. The purpose of this study was to examine the frequency of the INPP4B LOH and its association with the clinicopathological characteristics and prognosis...

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Identifiers

PMID: 26577950
DOI: 10.1016/j.breast.2015.10.006

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PTEN

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