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Article

Reduced expression of PTEN correlates with breast cancer progression.

Human pathology - 1 Apr 2002

Bose Shikha, Crane Allison, Hibshoosh Hanina, Mansukhani Mahesh, Sandweis Lynn, Parsons Ramon

Abstract excerpt

PTEN is a tumor-suppressor gene with phosphatase activity that is mutated in a variety of cancers. We analyzed a series of 34 invasive and 18 in situ breast cancers with known molecular status of the PTEN genotype using immunohistochemistry. Reduced PTEN protein expression was seen in 38% of inva...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12055674
DOI: 10.1053/hupa.2002.124721

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12055674-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Reduced expression of PTEN correlates with breast cancer progression.PMID 12055674Read ↗

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Tumor suppressor PTEN in breast cancer: heterozygosity, mutations and protein expression.Semantic proximity Read ↗

Prognostic and Predictive Implications of PTEN in Breast Cancer: Unfulfilled Promises but Intriguing PerspectivesSemantic proximity Read ↗

Frequent loss of PTEN expression is linked to elevated phosphorylated Akt levels, but not associated with p27 and cyclin D1 expression, in primary epithelial ovarian carcinomas.Semantic proximity Read ↗

Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosisSemantic proximity Read ↗

Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomasSemantic proximity Read ↗

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