Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.

Biochemical and biophysical research communications - 18 Oct 2013

Lopez Sandra M, Hodgson Myles C, Packianathan Charles, Bingol-Ozakpinar Ozlem, Uras Fikriye, Rosen Barry P, Agoulnik Irina U

Abstract excerpt

The tumor suppressor INPP4B is an important regulator of phosphatidyl-inositol signaling in the cell. Reduced INPP4B expression is associated with poor outcomes for breast, prostate, and ovarian cancer patients. INPP4B contains a CX5R catalytic motif characteristic of dual-specificity phosphatases, such as PTEN. Lipid phosphatase activity of INPP4B has previously been described. In this report we show that INPP4B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Dual-Specificity Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Models, Molecular

Share to Phosphatidate Phosphatase

Share to Phosphatidylinositol Phosphates

Share to Phosphoric Monoester Hydrolases

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 24070612
DOI: 10.1016/j.bbrc.2013.09.077
PMCID: PMC4578723

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.PMID 24070612Read ↗

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML.Semantic proximity Read ↗

INPP4B and PTEN Loss Leads to PI-3,4-P2 Accumulation and Inhibition of PI3K in TNBCSemantic proximity Read ↗

INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.Semantic proximity Read ↗

PTEN and Myotubularin: Novel Phosphoinositide PhosphatasesSemantic proximity Read ↗

Species-specific difference in expression and splice-site choice in Inpp5b, an inositol polyphosphate 5-phosphatase paralogous to the enzyme deficient in Lowe Syndrome.Semantic proximity Read ↗

The phosphoinositide 5-phosphatase INPP5K: From gene structure to in vivo functions.Semantic proximity Read ↗

PTEN proteoforms in biology and disease.Semantic proximity Read ↗

Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation.Semantic proximity Read ↗

Protein Tyrosine Phosphatase 1B (PTP1B): Insights into its New Implications in TumorigenesisSemantic proximity Read ↗

Role of INPP4B in the proliferation, migration, invasion, and survival of human endometrial cancer cells.Semantic proximity Read ↗

Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer.Semantic proximity Read ↗

Tailor-Made Protein Tyrosine Phosphatases: In Vitro Site-Directed Mutagenesis of PTEN and PTPRZ-B.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.