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Article

Tumor suppressor PTEN in breast cancer: heterozygosity, mutations and protein expression.

Anticancer research - 1 Mar 2014

Kechagioglou Petros, Papi Rigini M, Provatopoulou Xeni, Kalogera Eleni, Papadimitriou Elli, Grigoropoulos Petros, Nonni Aphroditi, Zografos George, Kyriakidis Dimitrios A, Gounaris Antonia

Abstract excerpt

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is one of the most frequently mutated human tumor suppressor genes, implicated in cell growth and survival and suppressing tumor formation. Loss of PTEN activity, either at the protein or genomic level, has been related to many primary and metastatic malignancies including breast cancer. The present study investigates the heterozygosity, mutation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Intraductal, Noninfiltrating

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Share to Chromosomes, Human, Pair 10

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Source

Identifiers

PMID: 24596386

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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