Article
Genetic Polymorphism and Expression of CXCR4 in Breast Cancer.
Analytical cellular pathology (Amsterdam) - 1 Jan 2015
Okuyama Kishima Marina, Brajão de Oliveira Karen, Ariza Carolina Batista, de Oliveira Carlos Eduardo Coral, Losi Guembarovski Roberta, Banin Hirata Bruna Karina, de Almeida Felipe Campos, Vitiello Glauco Akelinghton Freire, Trugilo Kleber Paiva, Guembarovski Alda Fiorina Maria Losi, Jorge Sobrinho Walter, Campos Clodoaldo Zago, Watanabe Maria Angelica Ehara
Abstract excerpt
CXCR4 genetic polymorphisms, as well as their expression level, have been associated with cancer development and prognosis. The present study aimed to investigate the influence of CXCR4 rs2228014 polymorphism on its mRNA and protein expression in breast cancer samples. It was observed that patients presented higher CXCR4 mRNA relative expression (5.7-fold) than normal mammary gland, but this expression was not...
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