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Article

Lymphadenectomy promotes tumor growth and cancer cell dissemination in the spontaneous RET mouse model of human uveal melanoma.

Oncotarget - 29 Dec 2015

Pin Yeo Kim, Khoo Karen, Tham Muly, Karwai Tan, Hwee Thiam Chung, Puaux Anne-Laure, Phua Meow Ling Cindy, Kato Masashi, Angeli Veronique, Abastado Jean-Pierre

Abstract excerpt

Resection of infiltrated tumor-draining lymph nodes (TDLNs) is a standard practice for the treatment of several cancers including breast cancer and melanoma. However, many randomized prospective trials have failed to show convincing clinical benefits associated with LN removal and the role of TDLNs in cancer dissemination is poorly understood. Here, we found in a well-characterized spontaneous mouse model of...

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Share to Cyclooxygenase 2 Inhibitors
Share to Lymph Node Excision

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Experimental

Share to Proto-Oncogene Proteins c-ret

Share to Tumor Burden

Share to Uveal Melanoma

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Share to Vascular Endothelial Growth Factor Receptor-1

Source

Open in PubMed Open full text

Identifiers

PMID: 26575174
DOI: 10.18632/oncotarget.6326
PMCID: PMC4792593

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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