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Article

Dormant non-culturable Mycobacterium tuberculosis retains stable low-abundant mRNA.

BMC genomics - 16 Nov 2015

Ignatov Dmitriy V, Salina Elena G, Fursov Mikhail V, Skvortsov Timofey A, Azhikina Tatyana L, Kaprelyants Arseny S

Abstract excerpt

BACKGROUND: Dormant Mycobacterium tuberculosis bacilli are believed to play an important role in latent tuberculosis infection. Previously, we have demonstrated that cultivation of M. tuberculosis in K(+)-deficient medium resulted in generation of dormant cells. These bacilli were non-culturable on solid media (a key feature of dormant M. tuberculosis in vivo) and characterized by low metabolism and tolerance to...

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Identifiers

PMID: 26573524
DOI: 10.1186/s12864-015-2197-6
PMCID: PMC4647672

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Source receipt: pubmed, retrieved 7 Sept 2026.

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