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Article

Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling.

Cells - 3 Jan 2021

Kwon Ji Hye, Kim Miyeon, Um Soyoun, Lee Hyang Ju, Bae Yun Kyung, Choi Soo Jin, Hwang Hyun Ho, Oh Wonil, Jin Hye Jin

Abstract excerpt

In order to provide a sufficient number of cells for clinical use, mesenchymal stem cells (MSCs) must be cultured for long-term expansion, which inevitably triggers cellular senescence. Although the small size of MSCs is known as a critical determinant of their fate, the main regulators of stem cell senescence and the underlying signaling have not been addressed. Umbilical cord blood-derived MSCs (UCB-MSCs) were...

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Identifiers

PMID: 33401590
DOI: 10.3390/cells10010063
PMCID: PMC7824096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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