Article
Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney.
Nature communications - 17 Nov 2015
Roy Angshumoy, Kumar Vijetha, Zorman Barry, Fang Erica, Haines Katherine M, Doddapaneni HarshaVardhan, Hampton Oliver A, White Simon, Bavle Abhishek A, Patel Nimesh R, Eldin Karen W, John Hicks M, Rakheja Dinesh, Leavey Patrick J, Skapek Stephen X, Amatruda James F, Nuchtern Jed G, Chintagumpala Murali M, Wheeler David A, Plon Sharon E, Sumazin Pavel, Parsons D Williams
Abstract excerpt
The X-linked BCL-6 co-repressor (BCOR) gene encodes a key constituent of a variant polycomb repressive complex (PRC) that is mutated or translocated in human cancers. Here we report on the identification of somatic internal tandem duplications (ITDs) clustering in the C terminus of BCOR in 23 of 27 (85%) pediatric clear cell sarcomas of the kidney (CCSK) from two independent cohorts. We profile CCSK tumours using...
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