Clear cell sarcomas of the kidney are characterised by <i><scp>BCOR</scp></i> gene abnormalities, including exon 15 internal tandem duplications and <i><scp>BCOR</scp>–<scp>CCNB</scp>3</i> gene fusion

Abstract excerpt

AIMS: Clear cell sarcoma of the kidney (CCSK) is a rare paediatric renal malignant tumour. The majority of CCSKs have internal tandem duplications (ITDs) of the BCOR gene, whereas a minority have the YWHAE-NUTM2 gene fusion. A third 'double-negative' (DN) category comprises CCSKs with neither BCOR ITDs nor YWHAE-NUTM2 fusion. The aim of this study was to characterise 11 histologically diagnosed CCSKs...

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