Article
LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease.
Oncotarget - 8 Dec 2015
Ceccarelli Sara, Panera Nadia, Mina Marco, Gnani Daniela, De Stefanis Cristiano, Crudele Annalisa, Rychlicki Chiara, Petrini Stefania, Bruscalupi Giovannella, Agostinelli Laura, Stronati Laura, Cucchiara Salvatore, Musso Giovanni, Furlanello Cesare, Svegliati-Baroni Gianluca, Nobili Valerio, Alisi Anna
Abstract excerpt
Lipopolysaccharide (LPS) is currently considered one of the major players in non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression. Here, we aim to investigate the possible role of LPS-induced TNF-α factor (LITAF) in inducing a pro-inflammatory and pro-fibrogenic phenotype of non-alcoholic steatohepatitis (NASH).We found that children with NAFLD displayed, in different liver-resident cells, an...
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