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Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)

25 Aug 2015

Abstract excerpt

Lipopolysaccharide-induced tumor necrosis factor-α factor (LITAF) exerts transcription factor activity and is involved in protein quality control. LITAF activity is highly dependent on correct translocation from the endosome/lysosome to the nucleus, while certain LITAF mutants mislocalize to areas, such as the cytosol and mitochondria, resulting in developmental diseases. In addition, previous studies have...

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PMID: 26324337
DOI: 10.3892/mmr.2015.4243

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