Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways.

doi:10.1007/s10295-016-1830-y

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Article

Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways.

Journal of industrial microbiology & biotechnology - 1 May 2017

Martín Juan F

Abstract excerpt

Penicillium chrysogenum is an excellent model fungus to study the molecular mechanisms of control of expression of secondary metabolite genes. A key global regulator of the biosynthesis of secondary metabolites is the LaeA protein that interacts with other components of the velvet complex (VelA, VelB, VelC, VosA). These components interact with LaeA and regulate expression of penicillin and PR-toxin biosynthetic...

Topics

Fungal Proteins
Gene Expression Regulation, Fungal
Genes, Fungal
Multigene Family
Mutation
Naphthols
Penicillins
Penicillium chrysogenum
beta-Lactams

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Open in PubMed

Identifiers

PMID: 27565675
DOI: 10.1007/s10295-016-1830-y

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