Article
Members of the Penicillium chrysogenum velvet complex play functionally opposing roles in the regulation of penicillin biosynthesis and conidiation.
Eukaryotic cell - 1 Feb 2013
Kopke Katarina, Hoff Birgit, Bloemendal Sandra, Katschorowski Alexandra, Kamerewerd Jens, Kück Ulrich
Abstract excerpt
A velvet multisubunit complex was recently detected in the filamentous fungus Penicillium chrysogenum, the major industrial producer of the β-lactam antibiotic penicillin. Core components of this complex are P. chrysogenum VelA (PcVelA) and PcLaeA, which regulate secondary metabolite production, hyphal morphology, conidiation, and pellet formation. Here we describe the characterization of PcVelB, PcVelC, and...
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