Article
Augmenting the Activity of Monoterpenoid Phenols against Fungal Pathogens Using 2-Hydroxy-4-methoxybenzaldehyde that Target Cell Wall Integrity.
International journal of molecular sciences - 10 Nov 2015
Kim Jong H, Chan Kathleen L, Mahoney Noreen
Abstract excerpt
Disruption of cell wall integrity system should be an effective strategy for control of fungal pathogens. To augment the cell wall disruption efficacy of monoterpenoid phenols (carvacrol, thymol), antimycotic potency of benzaldehyde derivatives that can serve as chemosensitizing agents were evaluated against strains of Saccharomyces cerevisiae wild type (WT), slt2Δ and bck1Δ (mutants of the mitogen-activated...
Topics
- Antifungal Agents
- Aspergillus fumigatus
- Benzaldehydes
- Cell Wall
- Cymenes
- Dioxoles
- Drug Synergism
- Gene Expression
- MAP Kinase Kinase Kinases
- Microbial Sensitivity Tests
- Mitogen-Activated Protein Kinases