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Cinnamic Acid Analogs as Intervention Catalysts for Overcoming Antifungal Tolerance.

Molecules (Basel, Switzerland) - 21 Oct 2017

Kim Jong H, Chan Kathleen L, Cheng Luisa W

Abstract excerpt

Disruption of fungal cell wall should be an effective intervention strategy. However, the cell wall-disrupting echinocandin drugs, such as caspofungin (CAS), cannot exterminate filamentous fungal pathogens during treatment. For potency improvement of cell wall-disrupting agents (CAS, octyl gallate (OG)), antifungal efficacy of thirty-three cinnamic acid derivatives was investigated against Saccharomyces...

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Caspofungin
Cinnamates
Dioxoles
Drug Tolerance
Echinocandins
Fungi

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PMID: 29065462
DOI: 10.3390/molecules22101783
PMCID: PMC6151797

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