Article
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.
Nature communications - 3 Jul 2020
Wilkes M C, Siva K, Chen J, Varetti G, Youn M Y, Chae H, Ek F, Olsson R, Lundbäck T, Dever D P, Nishimura T, Narla A, Glader B, Nakauchi H, Porteus M H, Repellin C E, Gazda H T, Lin S, Serrano M, Flygare J, Sakamoto K M
Abstract excerpt
Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome associated with ribosomal gene mutations that lead to ribosomal insufficiency. DBA is characterized by anemia, congenital anomalies, and cancer predisposition. Treatment for DBA is associated with significant morbidity. Here, we report the identification of Nemo-like kinase (NLK) as a potential target for DBA therapy. To identify new DBA...
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