Article
Does refining the phenotype improve replication rates? A review and replication of candidate gene studies on Major Depressive Disorder and Chronic Major Depressive Disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2016
Luo Xiaochen, Stavrakakis Nikolaos, Penninx Brenda W, Bosker Fokko J, Nolen Willem A, Boomsma Dorret I, de Geus Eco J, Smit Johan H, Snieder Harold, Nolte Ilja M, Hartman Catharina A
Abstract excerpt
Replication has been poor for previously reported candidate genes involved in Major Depressive Disorder (MDD). One possible reason is phenotypic and genetic heterogeneity. The present study replicated genetic associations with MDD as defined in DSM-IV and with a more narrowly defined MDD subtype with a chronic and severe course. We first conducted a systematic review of genetic association studies on MDD...
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