Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin Melanoma.

PloS one - 1 Jan 2015

Pyatnitskiy Mikhail, Karpov Dmitriy, Poverennaya Ekaterina, Lisitsa Andrey, Moshkovskii Sergei

Abstract excerpt

We propose an approach to detection of essential genes/proteins required for cancer cell survival. A gene is considered essential if a mutation with high impact upon the function of encoded protein causes death of the cancer cell. We draw an analogy between essential cancer proteins and well-known Abraham Wald's work on estimating the plane critical areas using data on survivability of aircraft encountering enemy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Melanocytes

Share to Melanoma

Share to Melanoma, Cutaneous Malignant

Share to Protein Interaction Mapping

Share to Semaphorins

Share to Skin Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 26565620
DOI: 10.1371/journal.pone.0142819
PMCID: PMC4643971

Genes

CCR5
CXCR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin Melanoma.PMID 26565620Read ↗

Bringing Down Cancer Aircraft: Searching For Essential Hypomutated Proteins In Skin MelanomaSemantic proximity Read ↗

Molecular Genomic Insights into Melanoma Associated Proteins PRAME and BAP1Semantic proximity Read ↗

Essentiality, Protein-Protein Interactions and Evolutionary Properties are Key Predictors for Identifying Cancer Genes Using Machine LearningSemantic proximity Read ↗

Gene alterations in inborn errors of immunity and their presence in cancers: Implications for oncogenesis, progression, and outcomes.Semantic proximity Read ↗

Essentiality, Protein-Protein Interactions and Evolutionary Properties are Key Predictors for Identifying Cancer-Associated Genes Using Machine LearningSemantic proximity Read ↗

Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidomeSemantic proximity Read ↗

New developments in dermatological oncogenetics.Semantic proximity Read ↗

Screening of key modules and key genes in the prevention of skin cancer development based on gene volcano plot and WGCNA.Semantic proximity Read ↗

The <i>Cancermuts</i> software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanomaSemantic proximity Read ↗

Odyssey of trefoil factors in cancer: Diagnostic and therapeutic implicationsSemantic proximity Read ↗

Somatic synonymous mutations in regulatory elements contribute to the genetic aetiology of melanoma.Semantic proximity Read ↗

Mutations in components of antiviral or microbial defense as a basis for breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.