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Article

Risk factors for anthracycline-associated cardiotoxicity.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 1 May 2016

Reinbolt Raquel E, Patel Roshan, Pan Xueliang, Timmers Cynthia Dawn, Pilarski Robert, Shapiro Charles L, Lustberg Maryam B

Abstract excerpt

PURPOSE: Carbonyl reductase (CBR) catalyzes anthracycline metabolism, and single nucleotide polymorphisms (SNPs) in CBR impact metabolic efficiency. In pediatric patients, homozygosity for the major allele (G) in the CBR3 gene was associated with increased risk of anthracycline cardiotoxicity. We hypothesized that CBR SNPs contribute to cardiotoxicity in adults. METHODS: We retrospectively identified female...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26563179
DOI: 10.1007/s00520-015-3008-y
PMCID: PMC4874738

Genes

CBR3
CBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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