Article
Possible Gender-Related Modulation by the ROCK1 Gene in Colorectal Cancer Susceptibility.
Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2015
Zucchini Cinzia, Martinelli Marcella, De Sanctis Paola, Rodia Maria Teresa, Mattei Gabriella, Ugolini Giampaolo, Montroni Isacco, Ghignone Federico, Solmi Rossella
Abstract excerpt
AIM: In view of accumulating evidence supporting a pivotal role of the Rho/ROCK pathway in cancer, we investigated Rho-kinase polymorphisms as potential susceptibility factors in colorectal cancer (CRC) in a representative sample of the Italian population. METHODS: DNA obtained from the peripheral blood samples of 137 CRC patients and 141 healthy controls was genotyped for four ROCK1 (rs35996865; rs73963110;...
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