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Article

Endothelial Nitric Oxide Synthase G894T Polymorphism Associates with Disease Severity in Puumala Hantavirus Infection.

PloS one - 1 Jan 2015

Koskela Sirpa, Laine Outi, Mäkelä Satu, Pessi Tanja, Tuomisto Sari, Huhtala Heini, Karhunen Pekka J, Pörsti Ilkka, Mustonen Jukka

Abstract excerpt

INTRODUCTION: Hantavirus infections are characterized by both activation and dysfunction of the endothelial cells. The underlying mechanisms of the disease pathogenesis are not fully understood. Here we tested the hypothesis whether the polymorphisms of endothelial nitric oxide synthase, eNOS G894T, and inducible nitric oxide synthase, iNOS G2087A, are associated with the severity of acute Puumala hantavirus...

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PMID: 26561052
DOI: 10.1371/journal.pone.0142872
PMCID: PMC4641644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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