Article
Endothelial nitric oxide synthase G894T (GLU298ASP) polymorphism is associated with hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organism.
Shock (Augusta, Ga.) - 1 May 2009
Huttunen Reetta, Hurme Mikko, Laine Janne, Eklund Carita, Vuento Risto, Aittoniemi Janne, Huhtala Heini, Syrjänen Jaana
Abstract excerpt
Nitric oxide (NO) as a vasoactive substance is a crucial element in the pathogenesis of sepsis. Endothelial NO synthase (eNOS) is, in turn, a key regulator of vascular NO production. The eNOS gene polymorphism at position 894 (G>T, Glu298Asp) resulting in T allele has been studied in the context of vascular diseases, but its role in sepsis has not yet been explored. We here studied the effect of eNOS Glu298Asp...
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