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Article

Effect of Mutations on the Binding of Kanamycin-B to RNA Hairpins Derived from the Mycobacterium tuberculosis Ribosomal A-Site.

Biochemistry - 29 Dec 2015

Truitt Amber R, Choi Bok-Eum, Li Jenny, Soto Ana Maria

Abstract excerpt

Kanamycin is an aminoglycoside antibiotic used in the treatment of drug-resistant tuberculosis. Mutations at the rRNA A-site have been associated with kanamycin resistance in Mycobacterium tuberculosis clinical isolates. Understanding the effect of these mutations on the conformation of the M. tuberculosis A-site is critical for understanding the mechanisms of antibiotic resistance in M. tuberculosis. In this...

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PMID: 26560864
DOI: 10.1021/acs.biochem.5b00710

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