Article
A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Nov 2010
Wang Kai, Guo Hong, Hu Huamei, Xiong Gang, Guan Xingying, Li Juan, Xu Xueqing, Yang Kang, Bai Yun
Abstract excerpt
MicroRNAs (miRNAs) are small, non-protein-coding RNAs that function as tumour suppressors or oncogenes. A single nucleotide change in the sequence of pre-miRNA can affect miRNA expression, so single-nucleotide polymorphisms (SNPs) in pre-miRNA may be biomarkers for biomedical applications. In this study, we performed a genetic association study between the SNP (rs11614913) in pre-miRNA-196a and esophageal...
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