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Article

A potential mode of action for Anakinra in patients with arthrofibrosis following total knee arthroplasty.

Scientific reports - 10 Nov 2015

Dixon David, Coates Jonathon, del Carpio Pons Alicia, Horabin Joanna, Walker Andrew, Abdul Nicole, Kalson Nicholas S, Brewster Nigel T, Weir David J, Deehan David J, Mann Derek A, Borthwick Lee A

Abstract excerpt

Arthrofibrosis is a fibroproliferative disease characterised by excessive deposition of extracellular matrix components intra-articularly leading to pain and restricted range of movement. Although frequently observed following total knee arthroplasty (TKA) no therapeutic options exist. A pilot study demonstrated that intra-articular injection of Anakinra, an IL-1R antagonist, improved range of movement and pain...

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Identifiers

PMID: 26553966
DOI: 10.1038/srep16466
PMCID: PMC4639732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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