Article
Induction of an inflammatory and prodegradative phenotype in autologous fibroblast-like synoviocytes by the infrapatellar fat pad from patients with knee osteoarthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Aug 2014
Eymard Florent, Pigenet Audrey, Citadelle Danièle, Flouzat-Lachaniette Charles-Henri, Poignard Alexandre, Benelli Chantal, Berenbaum Francis, Chevalier Xavier, Houard Xavier
Abstract excerpt
OBJECTIVE: The infrapatellar fat pad (IFP) of the knee joint has an inflammatory phenotype in osteoarthritis (OA). Its close proximity to the synovial membrane suggests that the IFP could be involved in the induction of OA synovitis. This study was undertaken to investigate the response of fibroblast-like synoviocytes (FLS) to autologous IFP and subcutaneous adipose tissue (SCAT) from patients with severe knee...
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