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Article

Species‐specific biological effects of FGF‐2 in articular cartilage: Implication for distinct roles within the FGF receptor family

13 Mar 2012

Abstract excerpt

Existing literature demonstrates that fibroblast growth factor-2 (FGF-2) exerts opposing, contradictory biological effects on cartilage homeostasis in different species. In human articular cartilage, FGF-2 plays a catabolic and anti-anabolic role in cartilage homeostasis, driving homeostasis toward degeneration and osteoarthritis (OA). In murine joints, however, FGF-2 has been identified as an anabolic mediator...

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PMID: 22415882
DOI: 10.1002/jcb.24129

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