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Article

Therapeutic landscape and future direction of metastatic colorectal cancer.

Nature reviews. Gastroenterology & hepatology - 1 May 2023

Bando Hideaki, Ohtsu Atsushi, Yoshino Takayuki

Abstract excerpt

In the era of targeted therapy based on genomic alterations, the treatment strategy for metastatic colorectal cancer (mCRC) has been changing. Before systemic treatment initiation, determination of tumour genomic status for KRAS and NRAS, BRAFV600E mutations, ERBB2, and microsatellite instability and/or mismatch repair (MMR) status is recommended. In patients with deficient MMR and BRAFV600E mCRC, randomized...

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PMID: 36670267
DOI: 10.1038/s41575-022-00736-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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