Article
Genomic characterization of mutant laboratory mouse strains by exome sequencing and annotation lift-over.
BMC genomics - 6 May 2015
Derdak Sophia, Sabrautzki Sibylle, de Angelis Martin Hrabě, Gut Marta, Gut Ivo G, Beltran Sergi
Abstract excerpt
BACKGROUND: Exome sequencing has become a popular method to evaluate undirected mutagenesis experiments in mice. However, the most suitable mouse strain for the biological model may be relatively distant from the standard mouse reference genome. For pinpointing causative variants, a matching reference with gene annotations is essential, but not always readily available. RESULTS: We present an approach that allows...
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