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Article

Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer.

The Journal of clinical investigation - 1 Dec 2015

Rondinelli Beatrice, Rosano Dalia, Antonini Elena, Frenquelli Michela, Montanini Laura, Huang DaChuan, Segalla Simona, Yoshihara Kosuke, Amin Samir B, Lazarevic Dejan, The Bin Tean, Verhaak Roel G W, Futreal P Andrew, Di Croce Luciano, Chin Lynda, Cittaro Davide, Tonon Giovanni

Abstract excerpt

Mutations in genes encoding chromatin-remodeling proteins are often identified in a variety of cancers. For example, the histone demethylase JARID1C is frequently inactivated in patients with clear cell renal cell carcinoma (ccRCC); however, it is largely unknown how JARID1C dysfunction promotes cancer. Here, we determined that JARID1C binds broadly to chromatin domains characterized by the trimethylation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26551685
DOI: 10.1172/JCI81040
PMCID: PMC4665784

Genes

DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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